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GNA's Red-Orange Complex - Skin Protection from Within

Red Orange Complex is a standardized extract derived from Red or Blood Oranges (Citrus sinensis). They are pigmented oranges with crimson and blood-coloured flesh, growing in the particular area surrounding Mount Etna volcano in Italy.

GNA Naturals Stock Oranges Image

Derived from Red or Blood Oranges (Citrus sinensis), this product helps with:

  • Reduce Skin Sensitivity to UV Radiation
  • Supports healthy skin before, during, and after you spend time outdoors
  • Prevention of cutaneous damage generated by UV sun exposure
  • Improves the homogeneity of skin tanning
  • Decrease oxidative stress in subjects with compromised anti-oxidative defenses such as smokers, sportsmen, diabetics, and people exposed to pollution.

GNA Naturals Red Orange Complex (ROC) is the perfect ingredient for ‘skin protection from within’ dietary supplements. Skin is the interface between the body and the environment. It acts as a barrier to the harmful effects of ultraviolet (UV) radiation and exogenous chemicals. 

GNA Naturals red orange complex H

ROC supports healthy skin before, during, and after you spend time outdoors. It enables skin to be evenly tanned and protects it against sun damage and photoaging. As we age, even moderate ultraviolet exposure takes its toll on skin health. ROC’s strong anti-oxidative properties have a positive impact on the whole body, helping to keep it healthy and slow down the aging process.

GNA Naturals Sun tan Image Stock

A recent clinical study has demonstrated the benefits of red orange intake and its protective effects on skin from UV-induced skin damage. 

  • Addition of ROC in keratinocyte cell culture confirms usefulness in prevention of cutaneous damage generated by UV sun exposure.
  • Oral ROC supplementation counteracts skin hyperpigmentation of solar lentigo induced by repeated UV exposure and improves the homogeneity of skin tanning.
  • Strong antioxidant activity confirmed in several clinical studies.
  • ROC is able to decrease oxidative stress in subjects with compromised anti-oxidative defenses such as smokers, sportsmen, diabetics, and people exposed to pollution.

Oxidative Medicine and Cellular Longevity’ Review Article: Red Orange: Experimental Models and Epidemiological Evidence of Its Benefits on Human Health

Discussed were the main health related properties of Red Orange Complex that include anti-cancer, anti-inflammatory, and cardiovascular protection activities. The effects of health of the main constituents of the Red Orange (namely, flavonoids, carotenoids, ascorbic acid, hydroxycinnamic acids, and anthocyanins) and their antioxidant activity and ability to modulate some key regulatory enzymes.

This article, Protective effect of red orange extract supplementation against UV-induced skin damages: photoaging and solar lentigines,” discusses the effects of ROC supplements and the exposure of the skin to solar ultraviolet (UV) radiation causes oxidative damages that result in clinical and histopathological changes, contributing to premature skin aging. Hyperpigmented lesions, also known as age spots, are one of the most visible alterations in skin photoaging.

GNA Naturals Stock Image Women Socking Sun

Skin is naturally equipped with antioxidant systems against UV-induced reactive oxygen species (ROS) generation; however, these antioxidant defenses are not completely efficient during exposure to sunlight. Oral antioxidants such as the ROC are able to counteract the harmful effects of UV radiation and to strengthen the physiological skin antioxidant defenses.


The present study was performed to evaluate the in vivo skin photo-protecting and anti-aging effects of a red orange (Citrus sinensis varieties Moro, Tarocco and Sanguinello) extract supplementation. Previous studies showed that red orange extracts possess strong in vitro free radical scavenging/antioxidant activity and photo-protective effects on human skin.


The photo-protective effects of red orange extract intake against UV-induced skin erythema and melanin production in solar lentigo was evaluated on healthy volunteers by an objective instrumental method (reflectance spectrophotometry).


Data obtained from in vivo studies showed that supplementation of red orange extract (100 mg/daily) for 15 days brought a significant reduction in the UV-induced skin erythema degree. Moreover, skin age spots pigmentation (melanin content) decreased from 27% to 7% when subjects were exposed to solar lamp during red orange extract supplementation.


Red orange extract intake can strengthen physiological antioxidant skin defenses, protecting skin from the damaging processes involved in photo-aging and leading to an improvement in skin appearance and pigmentation.

GNA Naturals Oranges Stock Image

In another article, “Oxidative stress in handball players: effect of supplementation with a red orange extract,” it talks about how athletes undergo intense physical exercise and this represents a condition that is often associated with increased production of reactive oxygen species (ROS) and free radicals in various tissues. Therefore, supplementation of antioxidants such as the Red-Orange Complex (ROC) may be desirable to reduce oxidative stress and provide a larger protective margin against its possible consequences.


The aim of the present study was to evaluate, in a group of professional handball players, the effects of short-term dietary supplementation with a standardized red orange extract (containing anthocyanins, flavanones, hydroxycinnamic acids, and ascorbic acid; Red Orange Complex [ROC]) on some noninvasive biomarkers of oxidative stress. 


Eighteen professional handball players and 17 healthy volunteers were enrolled in this study. The supplementation consisted of 50 mg ROC per capsule in micronized form; all subjects were recommended to take 1 capsule twice a day for 2 months.

GNA Naturals Stock Football Player


At the beginning of our study, serum TAS and SH group levels appeared significantly lower in players than in controls. After 2 months of ROC supplementation, both these parameters appeared unmodified in healthy subjects, but almost completely restored in players. 

Aldehydes and especially MDA have been frequently used as markers of oxidative damage. In trained athletes, we found, at the beginning of the study, circulating MDA levels significantly higher than those of control subjects, also if not in a statistically significant way; these values returned toward control values after 2 months of ROC supplementation. 

The ROC treatment was well tolerated by all subjects enrolled in the present trial because no unpleasant side effect was reported. The present findings reflect an overall lower level of oxidative stress in trained athletes after short-term dietary supplementation with the ROC. Although we cannot understand the exact mechanism subserving this beneficial effect, one could speculate that ROC ingredients protect endogenous antioxidants, such as vitamin C and E, from consumption by the oxidative process.


In conclusion, although preliminary, our results clearly demonstrate that dietary supplementation with the ROC (which is endowed with strong antioxidant capacity) is able to decrease oxidative stress and thus might protect against its short- and long-term health consequences in athletes engaged in regular training programs. Interestingly, besides being inexpensive, treatment with the ROC should have the additional advantage of being free of side effects.

GNA Naturals Sun Tanned Under Eyes

GNA Naturals Red-Orange Complex is truly a great “skin protection from within” dietary supplement. As discussed in numerous articles, specifically the two mentioned in this post, it is clinically proven that ROC helps significantly with:

  • Reduce skin sensitivity to UV radiation
  • Prevention of cutaneous damage generated by UV sun exposure like hyper-pigmentation in the skin.
  • Decrease oxidative stress in subjects with compromised anti-oxidative defenses such as smokers, sportsmen, diabetics, and people exposed to pollution.


  1. (NIH) National Institutes of Health
  2. Science Direct